Dosing

One pill, once a day, fits into men’s lives1

The only oral androgen deprivation therapy that offers convenient and injection-free administration.1,2

  • Mean effective half-life of ORGOVYX is 25 hours1
FIRST DAY
OF TREATMENT
  • Take 3 pills
  • 360 mg loading dose
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EVERY DAY
AFTER THAT
Image of 1 ORGOVYX pill
  • Take 1 pill
  • 120 mg daily dose
Pills not shown at actual size.
Actual size: 10.7 mm x 7.5 mm x 5.2 mm.3

After the initial loading dose,
patients take one pill, once a day1

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Can be taken with
or without food

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Should be taken around
the same time each day

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For oral administration only—
should be swallowed whole,
not crushed or chewed

  • In patients treated with GnRH receptor agonists and antagonists for prostate cancer, treatment is usually continued upon development of nonmetastatic or metastatic castration-resistant prostate cancer1
  • No dosage adjustment required in patients with mild to severe renal impairment or mild or moderate hepatic impairment1*

GnRH=gonadotropin-releasing hormone.

*The effect of end-stage renal disease with or without hemodialysis or severe hepatic impairment on the pharmacokinetics of ORGOVYX has not been evaluated.

Missed dose

  • Advise patients to take a missed dose of ORGOVYX as soon as they remember1
  • If the dose was missed by more than 12 hours, patients should not take the missed dose and resume with the next scheduled dose1
  • If treatment with ORGOVYX is interrupted for greater than 7 days, resume administration of ORGOVYX with a 360 mg loading dose on the first day, followed by 120 mg once a day1

DOSE MODIFICATION for USE WITH P-gp INHIBITORS OR COMBINED P-gp and Strong CYP3A Inducers

  • Avoid co-administration of ORGOVYX with oral P-gp inhibitors. If co-administration is unavoidable, take ORGOVYX first and separate dosing by at least 6 hours. Treatment with ORGOVYX may be interrupted for up to 2 weeks if a short course of treatment with a P-gp inhibitor is required1
  • Avoid co-administration of ORGOVYX with combined P-gp and strong CYP3A inducers. If co-administration is unavoidable, increase the ORGOVYX dose to 240 mg once a day. After discontinuation of the combined P-gp and strong CYP3A inducer, resume the recommended ORGOVYX dose of 120 mg once a day1
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PRESCRIBE ONCE-A-DAY ORAL ORGOVYX
FOR INJECTION-FREE ADMINISTRATION